The magic of chemical structures
Designing novel approaches for the synthesis of complex molecules and especially active pharmaceutical ingredients is an interesting subject in organic synthesis and it is the research interest of Dr. Saeed Balalaie, professor of chemistry at K. N. Toosi University of Technology, and his students. Dr. Balalaie was born in Iran in 1965, received his B.Sc. degree from the University of Tehran in 1989, his M.Sc. degree from Shahid Beheshti University in 1991, and his Ph.D. degree from Sharif University of Technology in 1996. He started his career as an assistant professor at K. N. Toosi University of Technology in 1997 and promoted to associate professor in 2003 and professor in 2007.
He received Alexander von Humboldt research fellowship in 2001 and worked with Professor Rolf Gleiter at the University of Heidelberg, Germany. He received six times research fellowship and also a linkage research group program award from Alexander von Humboldt Foundation (Prof. B. Breit, University of Freiburg). Recently, he received a research grant from German Research Center (DFG) through collaboration with Prof. G. Haberhauer (University of Duisburg-Essen). His research focuses on the synthesis of organic compounds through designing novel domino reaction, the development of efficient and selective synthetic methods, and also synthesis of peptides and cyclopeptides.
He established the Peptide Chemistry Research Institute with the goal of acquiring the know-how of synthesizing a variety of required active pharmaceutical ingredients of heterocyclic, nucleosides, and peptides in 2006. Despite all the limitations, great achievements have been made by his research group such as different APIs of peptides and also some novel peptides for medical imaging.
Now, there is an equipped laboratory in the research center and synthesize and analysis of novel APIs are common projects there. The list of the some synthesized compounds include: Triptoreline acetate, Leuprolide acetate, Fertirelin acetate, Angiotension II, Atosiban, Alarenine, Octrotide, Eptifibatide, Zoledronic acid, Fampira, Hynic-Octrotide, Hynic-Bombesin, Hynic-UBI, DOTA-Octrotate, Hynic-PSMA 11, DOTA-PSMA 617.
Meanwhile, there is a very good collaboration between peptide chemistry research center and different departments of Medicinal Chemistry, Biomaterial, Radiopharmacy, Biochemistry, Bioinformatics in different Universities to carrying out the common projects.